Job Description

Role Overview:

This role focuses on executing and supporting advanced protein analytics workflows including LC-MS, peptide mapping, and a variety of biophysical assays. The ideal candidate will bring hands-on experience with large molecule characterization and an eagerness to contribute in a fast-paced, multidisciplinary team environment.

Key Responsibilities:

• Operate and maintain mass spectrometry platforms for protein characterization (e.g., intact MS, peptide mapping).
• Perform data analysis using MS software and bioinformatics tools to assess quality attributes of therapeutic proteins and novel biologics.
• Execute biophysical assays such as SEC, HIC, CE-SDS, DSF, DLS, and Buffer Exchange.
• Generate and present frequent characterization summary reports.
• Troubleshoot automation methods and instrumentation to ensure high-throughput reliability.
• Follow and enhance SOPs related to biologics characterization.
• Document work in electronic laboratory notebooks (ELN) and support data reporting.

Qualifications & Skills:

Education:

• Minimum B.S. in Protein Sciences, Chemical/Bioengineering, Biochemistry, or related field.
• Advanced degrees and/or additional training are desirable.

Experience (Required):

• B.S. with 6+ years, M.S. with 4+ years, or Ph.D. with 1–3 years of relevant experience.
• Biotech or pharmaceutical industry experience preferred.

Technical Skills (Required):

• Experience with LC-MS sample preparation and operation for protein analysis.
• Familiarity with mass spectrometry data workflows and biophysical assay execution.
• Strong problem-solving, communication, and multitasking abilities.
• Proven ability to manage time and prioritize effectively in a lab-based role.

Preferred Skills:

• Hands-on experience with high-resolution MS instruments (e.g., Agilent Q-TOF, Thermo Orbitraps).
• Proficiency in MS software such as BioPharma Finder, BioConfirm; Empower experience is a plus.
• Familiarity with UPLC systems (Vanquish, Acquity), light scattering techniques, and ELN platforms.
• Experience working with large molecules, especially antibodies.

Additional Notes:

• This role requires 100% onsite presence in the lab.
• Candidates must be eager to work with various instruments, support collaborative discovery efforts, and continuously enhance workflows.
• Must-Haves: Experience with large molecules (e.g., antibodies), LC-MS expertise, strong documentation and data analysis skills.

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